- Promotor
- Co-promotor
- Date
- Tuesday 21 May 2024, 15:30 - 17:00
- Type
- PhD defence
- Space
- Professor Andries Querido room
- Building
- Education Center
- Location
- Erasmus MC
On Tuesday 21 May 2024, A. Bosman will defend the doctoral thesis titled: ‘Unravelling the Causes and Clinical Consequences of Phosphate Disturbances‘.
Brief summary of the doctoral thesis:
The aim of this thesis was to extend the knowledge on phosphate homeostasis and on causes and clinical consequences of phosphate disturbances. To achieve this, sex and age related differences in serum phosphate, and associations between serum phosphate and BMI and between serum phosphate and diuretic use were analyzed in the general population. Moreover, known causes of hypophosphatemia, including tumor-induced osteomalacia (TIO) and X-linked hypophosphatemia (XLH), were studied, as well as Cushing’s syndrome, a disease that is not commonly known to be associated with phosphate disturbances. Lastly, clinical consequences of phosphate disturbances were examined by studying disease characteristics of XLH patients and by exploring the causality of the association between serum phosphate and coronary artery calcification (CAC).
- More information
The public defence will begin exactly at 15.30 hrs. The doors will be closed once the public defence starts, latecomers can access the hall via the fourth floor. Due to the solemn nature of the ceremony, we recommend that you do not take children under the age of 6 to the first part of the ceremony.