ERC Advanced Grant
Erasmus MC, Department of Molecular Genetics
DNA damage and ageing
Hoeijmakers discovered that deficiencies in DNA repair processes in humans and mice accelerate ageing in virtually every organ. In addition, he established that quickly ageing mice that are put on a diet l see a 200% increase in their lifespan and remain far healthier. Hoeijmakers now wants to gain a clearer understanding of the mechanism behind this dietary restriction. In addition, he is examining how this knowledge can be applied in a clinical setting – for the benefit of patients suffering from accelerated ageing or early-onset dementia, for example. The results could contribute to healthy ageing and the prevention of ageing diseases like Alzheimer’s, Parkinson’s and cancer.