On Friday 28 October 2022, M.N. Ferrao Blanco will defend his PhD dissertation, entitled: ‘Pharmacological Treatments for Osteoarthritis: Emerging therapeutic strategies targeting chondrocyte hypertrophy and inflammation’.
- Promotor
- Co-promotor
- Date
- Friday 28 Oct 2022, 13:00 - 14:30
- Type
- PhD defence
- Space
- Senate Hall
- Building
- Erasmus Building
- Location
- Campus Woudestein
Dissertation in short:
Osteoarthritis (OA) is a disabling disease of the locomotor system that has no available cure. It has been identified as a serious disease determining morbidity, affecting more than 300 million people worldwide. OA is characterized by articular joint degeneration, where inflammation and loss of cartilage play an important role. In osteoarthritis, the cartilage cells, called chondrocytes, change their phenotype leading to cartilage damage. Factors secreted by inflammatory cells residing in the joint microenvironment, mainly macrophages, promote inflammation and further accelerate disease progression. Therefore, to develop an effective pharmacological treatment, we need to intervene in these key processes early in the disease, targeting chondrocyte phenotypical changes (hypertrophy) and inflammation. In this thesis I aimed to identify pharmacological targets for OA, targeting chondrocyte hypertrophy and inflammation.
- More information
The public defence will begin exactly at 13.00 hrs. The doors will be closed once the public defence starts, latecomers may be able to watch on the screen outside. There is no possibility of entrance during the first part of the ceremony. Due to the solemn nature of the ceremony, we recommend that you do not take children under the age of 6 to the first part of the ceremony.
A live stream link has been provided to the candidate.
