On Wednesday 20 May 2020, S.C. Migliardi- Doebar will defend her PhD dissertation, entitled: ‘Ductal Carcinoma in Situ: The Journey to Invasive Breast Cancer’.
DCIS (ductal carcinoma in situ) is a precursor lesion of invasive breast cancer. Although, about half of these lesions remain indolent and do not show progression to invasive breast cancer.
This thesis aims to unravel the underlying mechanisms of the transition from DCIS to IBC and to identify potential biomarkers to discriminate DCIS with a low invasive potential from DCIS with a high invasive potential. Further, we studied characteristics of precursor lesions in a large cohort of males with breast cancer in order to increase our understanding of carcinogenesis in this group of patients. A better understanding of the behavior of DCIS is needed to achieve personal treatment strategies in order to avoid over- or undertreatment.
The PhD defences will not take place publicly in the Senate Hall or Professor Andries Queridoroom due to the coronavirus. The candidates will defend their thesis online.