On Thursday 13 October 2022, X. Xu will defend his PhD dissertation, entitled: ‘The IL-17A/IL-17R Pathway in Immune-mediated Inflammatory Diseases’.
- Promotor
- Co-promotor
- Date
- Thursday 13 Oct 2022, 13:30 - 14:30
- Type
- PhD defence
- Space
- Senate Hall
- Building
- Erasmus Building
- Location
- Campus Woudestein
Dissertation in short:
The research described in this thesis focusses on the main question which role a unique protein of the immune system, called interleukin-17A (IL-17A), plays in the inflammation process in the joint and in the skin. IL-17A is a ‘messenger’, involved in the communication between different cells. Is the role of this ‘messenger’dependent on the type of inflammation where it is acting and will it be influenced by differences in target cells present at the site of inflammation? To study this we used two types of joint inflammatory conditions (types of arthritis) and two types of skin disorders. We found that IL-17A is involved in both joint and skin inflammation, showing overlap but also distinction depending on the type of inflammation. This information is important because it will help to stratify disease types and to fine-tune therapeutic treatment options for patients suffering with these types of diseases.
- More information
The public defence will begin exactly at 13.00 hrs. The doors will be closed once the public defence starts, latecomers may be able to watch on the screen outside. There is no possibility of entrance during the first part of the ceremony. Due to the solemn nature of the ceremony, we recommend that you do not take children under the age of 6 to the first part of the ceremony.
A live stream link has been provided to the candidate.
