On Tuesday 22 June 2021, D.A. Schipper will defend his PhD dissertation, entitled: ‘Metabolic and Inflammatory Aspects of Cardiothoracic Surgical Interventions’.
- Promotor
- Promotor
- Co-promotor
- Date
- Tuesday 22 Jun 2021, 15:30 - 17:00
- Type
- PhD defence
- Space
- Professor Andries Querido room
- Building
- Education Center
- Location
- Erasmus MC
In this thesis the metabolic and inflammatory aspects of various surgical interventions of the cardiopulmonary system are studied in three parts. After a general introduction (Chapter 1), part one (Chapters 2 and 3) describes the changes in bioenergetics and metabolism in patients with chronic cardiovascular disease, both at the mitochondrial and systemic level. In Chapter 2 demonstrates that oxygen consumption is diminished in mitochondria isolated from left atrial appendage tissue of patients that undergo coronary artery bypass grafting (CABG) surgery for chronic myocardial ischemia, as compared to non-ischemic control patients that suffer from cardiac valve disease. The decrease observed in this study could primarily be attributed to a loss of function of complex I. Chapter 3 investigates the influence of cardiac assist device implantation on whole body metabolism in a small cohort of end-stage heart failure patients. Here, implantation of total artificial hearts (TAH), but not of left ventricular assist devices (LVAD), was associated with an increase in resting energy expenditure (REE). This could mainly be attributed to the difference in working mechanism of both devices and the degree of surgically induced trauma.
Due to corona, the PhD defences do not take place publicly in the usual way in the Senate Hall or in the Professor Andries Querido Room. The candidates will defend their dissertation either in a small group or online.
