On Thursday 15 February 2024, J.M. Heijdra will defend the doctoral thesis titled: 'Individualizing Treatment in Von Willebrand Disease'.
- Promotor
- Promotor
- Promotor
- Date
- Thursday 15 Feb 2024, 10:30 - 12:00
- Type
- PhD defence
- Space
- Senate Hall
- Building
- Erasmus Building
- Location
- Campus Woudestein
Brief summary on the aim of the doctoral thesis:
The focus of this thesis was on individualizing dosing of treatment in von Willebrand disease (VWD), the most common inherited bleeding disorder. VWD is caused by a partial or complete absence of von Willebrand factor (VWF) (type 1 and type 3 VWD respectively) or by a functional defect of VWF (type 2 VWD). Symptoms mainly include mucocutaneous bleeding such as bruising, nose bleeds and menorrhagia, and bleeding after trauma or surgery. Due to its varying pathophysiology, diagnosis and treatment of VWD is complex. First, current treatment strategies were evaluated and reviewed to identify where improvements can be made. Secondly, several population pharmacokinetic (PK) models were developed, which can be applied for individualized PK-guided dosing of the currently available treatment. Thirdly, a study protocol on implementation of PKguided dosing of desmopressin and VWF-containing concentrates in clinical practice was presented, as well as new covariates that can be useful for future research.
- More information
The public defence will begin exactly at 10.30 hrs. The doors will be closed once the public defence starts, latecomers may be able to watch on the screen outside. There is no possibility of entrance during the first part of the ceremony. Due to the solemn nature of the ceremony, we recommend that you do not take children under the age of 6 to the first part of the ceremony.
