L. Harlaar will defend her PhD dissertation on Tuesday 21 March 2023, entitled: ’MRI Analysis of Diaphragmatic Weakness and Clinical Variation in Pompe Disease‘.
- Promotor
- Promotor
- Promotor
- Co-promotor
- Co-promotor
- Date
- Tuesday 21 Mar 2023, 10:30 - 12:00
- Type
- PhD defence
- Space
- Professor Andries Querido room
- Building
- Education Center
- Location
- Erasmus MC
Pompe disease is a slowly progressive muscle disease which can be treated with enzyme replacement therapy (ERT). However, the effect of ERT to skeletal muscles seems larger than the effect to respiratory muscles and there is a large variation in long-term treatment effects between individual patients.
In this thesis we used MRI to detect small changes in the motion and shape of the diaphragm that were not detected using regular pulmonary function tests. These MRI markers can help to detect early diaphragmatic weakness and to evaluate diaphragmatic weakness over time. Careful monitoring of individual patients is necessary to support treatment decisions, especially when hopefully stem cell therapies will be available.
- More information
The public defence will begin exactly at 10.30 hrs. The doors will be closed once the public defence starts, latecomers can access the hall via the fourth floor. Due to the solemn nature of the ceremony, we recommend that you do not take children under the age of 6 to the first part of the ceremony.
A live stream link has been provided to the candidate.
