On 9 February 2022, L.M.C. Koene will defend her PhD dissertation, entitled: ‘Seizing Epileptogenesis: Electrophysiological insights into mTOR-associated neurodevelopmental disorders’.
- Promotor
- Co-promotor
- Date
- Wednesday 9 Feb 2022, 10:30 - 12:00
- Type
- PhD defence
- Space
- Professor Andries Querido room
- Building
- Education Center
- Location
- Erasmus MC
Epilepsy is a common neurological disorder caused by abnormal increased neuronal activity in the brain. There is a striking high prevalence of epilepsy in neurodevelopmental disorders
including the rare disorders Tuberous sclerosis complex (TSC) and Focal cortical dysplasia (FCD); both related to increased activity of the mammalian target of rapamycin (mTOR)
pathway. However, it remains unknown how mTOR increase causes the development of epilepsy, a process called epileptogenesis. And to develop more efficient treatments,
the exact process of epilepsy needs to be better understood. Hence, this thesis aimed to identify mTOR-dependent mechanisms underlying epileptogenesis with patch-clamp
electrophysiology and molecular approaches.
The PhD defences will not take place publicly in the usual way. A live stream link has been provided to candidate. The ceremony will begin exactly at 10:30.
