M. Handula defends her thesis, entitled: Strategies Based on Peptide Antagonists to Improve Imaging and Treatment of Prostate Cancer and Neuroendocrine Tumors.
- Promotor
- Co-promotor
- Co-promotor
- Date
- Tuesday 17 Oct 2023, 13:00 - 14:30
- Type
- PhD defence
- Space
- Professor Andries Querido room
- Building
- Education Center
- Location
- Erasmus MC
Below is a brief summary of the dissertation:
My research focused on the use of peptide antagonists for imaging and treatment of prostate cancer and neuroendocrine tumors.
Peptide antagonists were used due to their outperformance compared to peptide agonists. As such, we synthesized and evaluated the potential of NeoB analogs (GPRP antagonists) for image-guided surgery of prostate cancer to help the surgeon to precisely remove the cancer tissue and limit the risk of disease recurrence. Besides, DOTA-JR11 and DOTA-JR11 analogs (SSTR2 antagonists) were used for enhanced treatment efficacy of neuroendocrine tumors based on different strategies such as the use of albumin binders and targeted alpha therapy.
- More information
The public defence will start exactly at 13.00hrs. The doors will be closed once the public defence starts, latecomers can access the hall via the fourth floor. Given the solemn nature of the event, we advise that children under the age of 6 not be brought to the first part of the ceremony.
A livestream link has been provided to candidate.
