On Tuesday 30 January 2024, M.A. Wesdorp will defend the doctoral thesis titled: ‘Promoting Endogenous Repair in Osteochondral Defects: Exploring therapeutic strategies and the impact of inflammation‘.
- Promotor
- Promotor
- Co-promotor
- Date
- Tuesday 30 Jan 2024, 15:30 - 17:00
- Type
- PhD defence
- Space
- Professor Andries Querido room
- Building
- Education Center
- Location
- Erasmus MC
Brief summary on the aim of the doctoral thesis:
This thesis focuses on the use of an endogenous approach to stimulate repair of osteochondral defects. In order to achieve successful repair of the defect, it is important for mesenchymal stromal cells (MSCs) to migrate to the defect area (or, in the case of a biomaterial-assisted approach, into the scaffold) and deposit extracellular matrix (ECM). However, the inflammatory environment present at the defect site influences MSC migration and ECM synthesis. Biomaterials, which provide a scaffold for MSC migration and ECM deposition, can also affect the repair process through the induction of an inflammatory response. Understanding the relationship between MSC migration, inflammation, and biomaterials is crucial for the optimization of endogenous repair strategies.
- More information
The public defence will begin exactly at 15.30 hrs. The doors will be closed once the public defence starts, latecomers can access the hall via the fourth floor. Due to the solemn nature of the ceremony, we recommend that you do not take children under the age of 6 to the first part of the ceremony.
