On 24 February 2022, R.C. Hoogeveen will defend his PhD dissertation, entitled: ‘A War of Exhaustion: T cell signatures in hepatitis B virus infection’.
- Promotor
- Co-promotor
- Co-promotor
- Date
- Thursday 24 Feb 2022, 10:30 - 12:00
- Type
- PhD defence
- Space
- Senate Hall
- Building
- Erasmus Building
- Location
- Campus Woudestein
Hepatitis B is caused by an hepatotropic virus that leads to either an acute selflimiting infection or chronic disease. The natural history of chronic HBV infection is rather diverse, and ranges from asymptomatic patients with minimal viral replication, to patients with high levels of viral replication, fulminant hepatitis and liver failure. The complex viral life cycle and differing disease stages are accompanied by an equally complicated response from the host immune system. Why HBV is capable of persisting in those patients affected early on in life, whereas adults are capable of controlling HBV replication long-term remains largely undefined. Virus-specific T cells are indispensable for a sustained control of HBV, as observed in human and animal studies, but what kind of T cell responses is required remains ill defined.
The PhD defences will not take place publicly in the usual way. A live stream link has been provided to candidate. The ceremony will begin exactly at 10:30.
