- Promotor
- Co-promotor
- Date
- Wednesday 31 May 2023, 10:30 - 12:00
- Type
- PhD defence
- Space
- Professor Andries Querido room
- Building
- Education Center
- Location
- Erasmus MC
R.L. Goetgebuer will defend his PhD dissertation on Wednesday 31 May 2023, entitled: ’Viral Infections and Complications in Inflammatory Bowel Disease‘.
Summary:
This thesis aimed to clarify the impact of several viral infections, their complications and vaccination responses in patients with inflammatory bowel disease (IBD). The first part focuses on two herpes viruses, Epstein-Barr virus (EBV) and cytomegalovirus (CMV), that can cause severe opportunistic infections, mostly as a rare complication of the use of immunosuppressants. In the second part we studied the risk of the premalignant condition cervical intraepithelial neoplasia (CIN) and cervical cancer caused by human papillomavirus (HPV) in women with IBD and we aimed to identify risk factors, in particular by studying the exposure to immunosuppressants in detail. The third part describes an uncommon case of a hepatitis E virus (HEV) infection in a patient using the gut-selective biologic agent vedolizumab. In the last part of this thesis, we focused on vaccination responses to influenza vaccination and severe acute respiratory coronavirus 2 (SARS-Cov-2) vaccination in immunocompromised patients with IBD and other immune-mediated inflammatory diseases (IMID).
- More information
The public defence will begin exactly at 10.30 hrs. The doors will be closed once the public defence starts, latecomers can access the hall via the fourth floor. Due to the solemn nature of the ceremony, we recommend that you do not take children under the age of 6 to the first part of the ceremony.
A live stream link has been provided to the candidate.