T. Robert Finestra will defend her PhD dissertation on Tuesday, 31 October 2023, entitled: ’Breaking the Balance: The initial steps of X chromosome inactivation‘.
- Promotor
- Promotor
- Co-promotor
- Co-promotor
- Date
- Tuesday 31 Oct 2023, 10:30 - 12:00
- Type
- PhD defence
- Space
- Professor Andries Querido room
- Building
- Erasmus Building
- Location
- Erasmus MC
Below is a brief summary about the dissertation:
Female placental mammals randomly inactivate one X chromosome to compensate for gene dosage imbalances between females (XX) and males (XY). This process is known as X Chromosome Inactivation (XCI) and has numerous implications for health and disease. At the molecular level, XCI is regulated through a complex interplay of factors and regulatory mechanisms that ensure that a single X chromosome remains active per diploid genome early during embryonic development. Although significant progress has been made in understanding the molecular mechanisms underlying XCI, essential questions remain unanswered. This thesis aims to further clarify the initial steps of XCI and explore novel factors that potentially act in XCI, using genetically modified female mouse Embryonic Stem Cells combined with multiple omics and microscopy techniques.
- More information
The public defence will begin exactly at 10.30 hrs. The doors will be closed once the public defence starts, latecomers can access the hall via the fourth floor. Due to the solemn nature of the ceremony, we recommend that you do not take children under the age of 6 to the first part of the ceremony.
A live stream link has been provided to the candidate.
