On Tuesday 13 September 2022, X. Zhang will defend her PhD dissertation, entitled: ‘Molecular Epidemiology towards Deciphering Underlying Mechanisms of Fatty Liver Disease’.
- Promotor
- Co-promotor
- Date
- Tuesday 13 Sep 2022, 15:30 - 17:00
- Type
- PhD defence
- Space
- Professor Andries Querido room
- Building
- Education Center
- Location
- Erasmus MC
Dissertation in short:
A substantial burden of illness and mortality worldwide is caused by fatty liver disease (FLD) and its complications, including type 2 diabetes (T2D), obesity, hypertension, and dyslipidemia. Among the FLD patients, the majority of fatty liver patients develop non-alcoholic fatty liver disease (NAFLD), which is the most common cause of chronic liver disease worldwide. Although there are no or few symptoms, a subpopulation can progress to end-stage liver disease or even liver cancer. Recently, a consensus by an international panel of experts recommended a change in name for NAFLD to metabolic dysfunction associated fatty liver disease (MAFLD). It does not only eliminate alcohol from both the name and definition. However, the underlying mechanism of FLD and how to early diagnose FLD are still not clear. Understanding the pathophysiology of FLD can help to facilitate the prevention and treatment strategies. In this thesis, I aim to provide novel insights into the molecular mechanisms of FLD through several omics approaches and integration of multi-omics, centering on genomics, transcriptomics,
metabolomics, and gut microbiota.
- More information
The public defence will begin exactly at 15.30 hrs. The doors will be closed once the public defence starts, latecomers can access the hall via the fourth floor. Due to the solemn nature of the ceremony, we recommend that you do not take children under the age of 6 to the first part of the ceremony.
A live stream link has been provided to the candidate.
