On Wednesday 14 September 2022, A.A. Rijkse will defend her PhD dissertation, entitled: ‘Kidney Transplantation. Extending criteria for donation and implantation.’.
- Promotor
- Co-promotor
- Date
- Wednesday 14 Sep 2022, 10:30 - 12:00
- Type
- PhD defence
- Space
- Professor Andries Querido room
- Building
- Education Center
- Location
- Erasmus MC
Dissertation in short:
Kidney transplantation is the best therapy for end-stage renal disease. Because of the large gap between demand and supply of suitable grafts, there is an increase in acceptance of extended criteria donor grafts that may have suboptimal outcomes. Due to ageing of the end-stage renal disease population, there is also an increase in the prevalence of extended criteria recipients with potential suboptimal outcomes, such as patients with aorto-iliac vascular disease. The reason that aorto-iliac vascular disease is considered suboptimal is due to technical challenges during the operation and the potential effect on post-transplant outcomes. Given that severe aorto-iliac vascular disease is considered as a relative contra-indication for transplantation, transplant outcomes of these patients are not adequately studied.
The overall aim of this thesis was to answer questions related to extending criteria for donation or implantation. Part I focused on extending criteria for donation, Part II on aorto-iliac calcification as extended criterion for implantation and Part III on aorto-iliac stenosis as extended criterion for implantation.
We aimed to answer the following research questions:
Part I Extending criteria for donation
1.Should donation after circulatory death (DCD) kidneys be considered as suboptimal kidneys interms of inferior short- and long-term transplant outcomes?
2.What is the role and current clinical application of dynamic preservation techniques inimproving outcomes of suboptimal donor kidneys in the Netherlands?
3.What is the role of normothermic machine perfusion (NMP) in suboptimal donor kidneys?
Part II Extending criteria for implantation: aorto-iliac calcification
4.What is the prognosis of kidney transplantation in the presence of aorto-iliac calcification interms of patient survival, graft survival and graft function?
5.What is the current practice regarding screening, management and acceptance of patientswith aorto-iliac vascular disease for transplantation?
Part III Extending criteria for implantation: aorto-iliac stenosis
6.Can we accurately predict the risk of a hemodynamically significant aorto-iliac stenosis todefine guidelines on the feasibility of a successful kidney transplantation?
7.What is the prognosis of kidney transplantation in the presence of a hemodynamicallysignificant aorto-iliac stenosis in terms of patient survival, graft survival and cardiovascularevents
- More information
The public defence will begin exactly at 10.30 hrs. The doors will be closed once the public defence starts, latecomers can access the hall via the fourth floor. Due to the solemn nature of the ceremony, we recommend that you do not take children under the age of 6 to the first part of the ceremony.
A live stream link has been provided to the candidate.
