PhD defence B.A.M. (Berthe) van der Geest

Neonatal hyperbilirubinaemia: Moving towards screening and treatment in primary care
Promotor

Prof. dr. E.A.P. Steegers

Promotor

Prof. dr. I.K.M. Reiss

Co-promotor

Dr. J.V. Been

Date
Wednesday 14 Dec 2022, 13:00 - 14:30
Type
PhD defence
Space
Professor Andries Querido room
Building
Education Center
Location
Erasmus MC
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B.A.M. van der Geest will defend her PhD dissertation on Wednesday 14 December 2022, entitled: ’Neonatal hyperbilirubinaemia: Moving towards screening and treatment in primary care‘.

Summary:

Jaundice is a common phenomenon in babies during the first days of life. In most babies, jaundice resolves spontaneously. However, in some babies, the substance that causes jaundice, bilirubin, may raise to extreme levels and may cause brain damage. Hence, it is important to recognise and treat these babies in time.

In this thesis, we show that severe jaundice still occurs in the Netherlands. Guidelines are regularly not adhered to in babies with severe jaundice. Non-adherence to the guideline is often not mentioned as improvable factor. Additionally, a wait-and-see approach regarding neonatal jaundice is often performed, even in severely jaundiced babies. To improve recognition and treatment of neonatal jaundice, a large trial was conducted (STARSHIP Trial). In this trial, (1) daily measurements of the degree of jaundice of the skin and (2) treatment of neonatal jaundice were performed in seven primary care birth centres (rather than in the hospital). The first, preliminary results show that hospital admission was avoided in approximately 85% of the babies after implementation of treatment for neonatal jaundice in primary care birth centres. Parents were generally satisfied with this treatment. 

Not all babies in the Netherlands are cared for in a primary care birth centre during the first days of life. Consequently, it is important to improve recognition of severe jaundice at home as well. A new trial has been designed to research new screening and diagnostic methods at home (BEAT jaundice@home study). The design of this trial is also described in this thesis.

The findings presented in this thesis may contribute to avoid severe jaundice and its potentially lifelong consequences in the future.

More information

The public defence will begin exactly at 13.00 hrs. The doors will be closed once the public defence starts, latecomers can access the hall via the fourth floor. Due to the solemn nature of the ceremony, we recommend that you do not take children under the age of 6 to the first part of the ceremony.

A live stream link has been provided to the candidate.

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