E. Brivio will defend her PhD dissertation on Tuesday 12 September, entitled: ’Pediatric Leukemia: New treatment opportunities‘.
- Promotor
- Promotor
- Co-promotor
- Date
- Tuesday 12 Sep 2023, 13:00 - 14:30
- Type
- PhD defence
- Space
- Professor Andries Querido room
- Building
- Education Center
- Location
- Erasmus MC
Below is a brief summary of the dissertation:
This thesis is focused on new therapeutic options for pediatric acute lymphoblastic leukemia (ALL) and chronic myeloid leukemia (CML). We provide the results of two ‘first-in-child’ clinical trials, developed in the context of Pediatric Investigational Plans (PIPs), with the final aim to inform the Regulatory Authority and obtain approval of inotuzumab ozogamicin (InO) and bosutinib for pediatric use.
The majority of drugs we use in pediatric oncology are not approved for the indication, and sometimes not even for use in children. In fact, development and approval of new agents for pediatric cancers lags behind adult development. New regulations in Europe and U.S. are enacted to ensure commitment of companies to develop drugs in children, but current incentives are still insufficiently attractive for pharmaceutical companies. Clinical trials in children, especially early phase 1-2 studies, are challenging due to the small number of patients with cancer and relapsed or refractory disease.
- More information
The public defence will begin exactly at 13.00 hrs. The doors will be closed once the public defence starts, latecomers can access the hall via the fourth floor. Due to the solemn nature of the ceremony, we recommend that you do not take children under the age of 6 to the first part of the ceremony.
A live stream link has been provided to the candidate.
