G.D.M. Veerman will defend his PhD dissertation on Wednesday 21 June 2023, entitled: ’Personalising Small-Molecule Kinase Inhibitor Treatment for Patients with Non-Small Cell Lung Cancer‘.
- Promotor
- Promotor
- Date
- Wednesday 21 Jun 2023, 13:00 - 14:30
- Type
- PhD defence
- Space
- Professor Andries Querido room
- Building
- Education Center
- Location
- Erasmus MC
Summary:
Tyrosine kinase inhibitors (TKIs) are used to target certain forms of metastatic lung cancer. If a treatable genetic alteration is demonstrated after pathological examination, treatment with TKIs is preferable to classical chemotherapy or immunotherapy. TKIs are tablets to be taken daily. Using TKIs has increased the survival time and quality of life of the overall patient group.
However, there are also patients where TKIs have no effect or serious (life-threatening) side effects occur. Many factors influence this, including pharmacokinetics. This refers to the processes of absorption, distribution, metabolism and excretion of drugs. Pharmacokinetics ensures a certain exposure of the TKI to the body and tumours. This exposure varies between individuals (interpatient variability), but also within an individual (intrapatient variability). For every drug, there is an area of exposure within which the drug is effective, and no serious side effects occur: the therapeutic window. This optimal balance can be pursued for each patient (personalised) for the best possible treatment of his or her lung cancer. The studies in this thesis aim to improve the pharmacological personalisation of TKIs.
- More information
The public defence will begin exactly at 13.00 hrs. The doors will be closed once the public defence starts, latecomers can access the hall via the fourth floor. Due to the solemn nature of the ceremony, we recommend that you do not take children under the age of 6 to the first part of the ceremony.
A live stream link has been provided to the candidate.
