PhD defence H.A. (Hiltje) Geuzinge

Breast Cancer Screening for Women at Increased Risk: Comparing MRI with Mammography
Promotor
Prof. dr. H.J. de Koning
Promotor
Prof. dr. C. Verhoef
Co-promotor
Dr. E.A.M. Heijnsdijk
Date
Tuesday 24 May 2022, 15:30 - 17:00
Type
PhD defence
Space
Professor Andries Querido room
Building
Education Center
Location
Erasmus MC
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On 24 May 2022, H.A. Geuzinge will defend her PhD dissertation, entitled: ‘Breast Cancer Screening for Women at Increased Risk: Comparing MRI with Mammography’.

Dissertation in short:

Breast cancer is the most common cancer among women. In the Netherlands, women aged 50 to 74 years are invited for biennial mammography screening within a national screening program. Women at high risk of developing breast cancer due to a BRCA1/2 or TP53 pathogenic variant are invited for MRI and mammography screening outside the national screening program. Apart from these high-risk women, more groups of women may benefit from MRI screening. For example, women with extremely dense breast tissue: in those women, performance of mammography is generally poor and they have a higher breast cancer risk than women with a lower breast density. Also, women with a pathogenic variant in ATM, CHEK2 and PALB2 genes, and women with a breast cancer family history without a known a pathogenic variant in BRCA1/2 or TP53 genes may benefit from MRI screening. The aim of this thesis was to evaluate whether MRI screening would be an acceptable screening modality for women at increased breast cancer risk. Risk groups included in this thesis were women with a breast cancer family history without a known causative gene mutation, women with a pathogenic variant in ATM, PALB2 or CHEK2 genes, and women with extremely dense breast tissue.

More information

The public defence will begin exactly at 15.30 hrs. The doors will be closed once the public defence starts, latecomers can access the hall via the fourth floor. Due to the solemn nature of the ceremony, we recommend that you do not take children under the age of 6 to the first part of the ceremony.

A live stream link has been provided to the candidate.

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