PhD defence K. (Karin) Huizer
- Prof.dr. J.M. Kros
- Dr. D.A.M. Mustafa
- Dr. A. Sacchetti
On Tuesday 1 December 2020, K. Huizer will defend her PhD dissertation, entitled: ‘Glioma Neovascularization: The Plot Thickens’.
The overall aim of our project was to elucidate the role of both the tumor microenvironment and macro-environment (the blood) in glioblastoma (GBM) neovascularization, with a focus on circulating angiogenic cells (CACs). More specifically, we aimed to answer the following questions:
1) Which subtypes of CACs are mainly involved in GBM neovascularization compared to regenerative neovascularization (as represented by myocardial infarction, MI; Chapter 3)?
2) Do qualitative (gene expression) differences exist within CAC subsets between GBM and regenerative (MI) and developmental (fetal) neovascularization. If so, which (treatmenttargetable) genes are predominantly involved (Chapter 4)?
3) What is the cellular source and the role of the matricellular protein periostin in GBM vessel formation (Chapter 5)?
To answer questions 1 and 2, we formulated the additional research question:
4) How can CAC subsets be best identified, characterized and isolated using Fluorescence-Activated Cell Sorting (FACS; Chapter 2)?
Due to corona, the PhD defences do not take place publicly in the usual way in the Senate Hall of the Professor Andries Querido Room. The candidates will defend their dissertation either in a small group or online.