PhD defence L. (Lisanne) Noordam

Engaging the Immune System in the Fight Against Cancer
Prof. dr. M.J. Bruno
Dr. J. Kwekkeboom
Tuesday 20 Jun 2023, 13:00 - 14:30
PhD defence
Professor Andries Querido room
Education Center
Erasmus MC
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L. Noordam will defend her PhD dissertation on Tuesday 20 June 2023, entiteld: Engaging the Immune System in the Fight Against Cancer.


The aim of this thesis was to improve the treatment of cancer by manipulation of the immune system. In chapters 2 and 3 the effects of several immune checkpoint inhibitors and stimulators were evaluated on T cells isolated from several types of cancer. Blockade of the inhibiting immune checkpoint receptors LAG3 and PD-L1 promoted the ex vivo capacities of intra-tumoral T cells isolated from liver metastases of mismatch repair proficient colorectal carcinomas. In the proof-of-concept study, described in Chapter 3, the biclonic CD137xPD-L1 antibody stimulated proliferation of intratumoral T cells isolated from hepatocellular carcinoma samples. In chapters 4 and 5 a vaccination strategy was explored; in chapter 4 a panel of 12 tumor antigens was found to be expressed in the majority of hepatocellular carcinoma patients and in chapter 5 the immunogenicity of several of these antigens was explored. Interestingly, the expression of tumor antigens in adjacent macroscopically tumor-free tissues was a predictive factor for tumor recurrence. Finally, the effect of low-dose cyclophosphamide on circulating regulatory T cells was evaluated in patients synergistically treated with dendritic cell therapy, as a manner to reduce the immunosuppressive environment and tip the balance.

More information

The public defence will start exactly at 13.00 hrs. The doors will be closed once the public defence starts, latecomers can access the hall via the fourth floor. Given the solemn nature of the event, we advise that children under the age of 6 not be brought to the first part of the ceremony.

A livestream link has been provided to candidate.

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