PhD defence L. (Lucie) de Jonge

Safeguarding the Cost-Effectiveness of Organized Colorectal Cancer Screening Programs: Lessons learned from (unforeseen) real-life events
Prof.dr. I. Lansdorp-Vogelaar
Dr. E. Toes-Zoutendijk
Thursday 7 Mar 2024, 15:30 - 17:00
PhD defence
Senate Hall
Erasmus Building
Campus Woudestein
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On Thursday 7 March 2024, L. de Jonge will defend the doctoral thesis titled: ‘Safeguarding the Cost-Effectiveness of Organized Colorectal Cancer Screening Programs: Lessons learned from (unforeseen) real-life events‘.

Brief summary of the doctoral thesis:

Colorectal cancer (CRC) is a global health problem ranked as the third most common cancer in the world. Screening has proven to decrease CRC incidence and CRC-related mortality through the  removal of precursor lesions and of cancers detected in an early stage. Therefore, many countries have implemented an organized CRC screening program using colonoscopy screening or fecal immunochemical test (FIT) screening.  Using microsimulation and observational data from screening programs, the aim of this thesis is to investigate how to safeguard the (cost-)effectiveness of CRC screening programs. The research consisted of three topics: evaluation and monitoring, CRC screening during COVID-19 and new developments. The first part is comprised of studies with examples and methodologies of evaluating and monitoring CRC screening programs. In the second part, the impact of the COVID-19 pandemic on CRC screening was investigated as many programs were temporarily suspended or operating at restricted capacity. The third part consisted of studies investigating new developments in CRC screening: a new screening test and risk-based screening. Based on the results of this thesis, the authors suggested that in order to safeguard the effectiveness of CRC screening programs, large evaluations of population-based organized CRC screening programs should be conducted to evaluate whether actual outcomes of the program are meeting expectations. Moreover, microsimulation models for CRC should be used to extrapolate (existing) evidence and determine the optimal screening strategy when real-life data is not (yet) available.

More information

The public defence will begin exactly at 15.30 hrs. The doors will be closed once the public defence starts, latecomers may be able to watch on the screen outside. There is no possibility of entrance during the first part of the ceremony. Due to the solemn nature of the ceremony, we recommend that you do not take children under the age of 6 to the first part of the ceremony. 

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