- Thursday 1 Sep 2022, 10:30 - 12:00
- PhD defence
- Senate Hall
- Erasmus Building
- Campus Woudestein
On Thursday, 1 September 2022, Y. (Ylenia) Ingrasciotta will defend her PhD dissertation, entitled: ‘Insight into Real-world use and Benefit-risk Profile of Biologics and Frequently Prescribed Drugs in Aging Populations’.
Dissertation in short:
Elderly patients are often not included in randomized clinical trials (RCTs) evaluating efficacy and safety of new drugs. Such exclusions may impair the generalizability of RCT results in real-world settings. Therefore, drugs prescription, especially biologic drugs, to elderly is challenging. The increasing use of biologics in clinical practice gave rise to safety concerns, such as the risk of hypersensitivity reactions, immunogenicity, infections and cancer. The pressing need for thorough post-marketing monitoring of these drugs became clear. The availability and secondary use of claims databases with electronic health records of millions of persons offer the opportunity to get better insights into real-world drug use and the risks and benefits of those medications in community dwelling elderly persons.