PhD Defence A. (Amir) Omidvari Abarghouei

In this thesis, we have used the Microsimulation  Screening Analysis Esophageal Adenocarcinoma (MISCAN-EAC) model to conduct cost-effectiveness analyses on BE screening and surveillance strategies. In the first part, we have focused on screening for BE and evaluated the cost-effectiveness of using Cytosponge as a minimally invasive method to screen high-risk people for BE. Then we assessed the impact of including unrelated health effects and costs on our cost-effectiveness estimates.

In the second part, we synthesized the literature on the cost-effectiveness of surveillance recommendations and evaluated several ways to further improve the cost-effectiveness of surveillance by optimizing several aspects of BE management, including optimal management of BE patients with LGD or no dysplasia, and stopping age of surveillance of non-dysplastic BE patients. Subsequently, we evaluated how the lack of adherence to surveillance guidelines for BE patients can impact cost-effectiveness estimates.

Due to corona, the PhD defences do not take place publicly in the usual way in the Senate Hall of the Professor Andries Querido Room. The candidates will defend their dissertation either in a small group or online.