PhD defence C.G. (Cindy) Boer
- Prof. Dr. A.G. Uitterlinden
- Dr. J.B.J. van Meurs
On Tuesday 15 December 2020, C.G. Boer will defend her PhD dissertation, entitled: ‘Osteoarthritis: genetics and phenotypes in all their complexity’.
The aim of this thesis is to identify novel genes involved in the pathogenesis of osteoarthritis, in order to gain greater insight into the pathology of osteoarthritis and bring possible preventive or curative treatments closer for one of the world’s oldest diseases.
In Chapter 2, osteoarthritis endophenotypes and structural phenotypes are used to increase GWAS power and identify novel genes associated with osteoarthritis. Next, , in Chapter 3 also the interaction with the environment is investigated, in particular the use of vitamin K antagonists, to identify novel, and perhaps modifiable, genetic influences associated with osteoarthritis. In Chapter 4, the results of the largest GWAS to multiple osteoarthritis phenotypes is presented, including functional follow-up to identity possible causal genes. Lastly, in Chapter 5, the possible influence of the gastrointestinal microbiome composition on osteoarthritis related knee pain and inflammation is investigated.
Due to corona, the PhD defences do not take place publicly in the usual way in the Senate Hall of the Professor Andries Querido Room. The candidates will defend their dissertation either in a small group or online.