PhD defence J.F. (Jesse) Veenis


Prof.dr. F. Zijlstra


Dr. J.J. Brugts

Wednesday 6 Jan 2021, 15:30 - 17:00
PhD defence
Spoken Language
Professor Andries Querido room
Education Center
Erasmus MC
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On Wednesday 6 January 2021, J.F. Veenis will defend his PhD dissertation, entitled: ‘Optimized and Individualized Medicine in Heart Failure Therapy: The next step forward’.

This thesis contributes to further optimize heart failure and left ventricular assist device care. We demonstrated that the care for chronic heart failure patients at Dutch outpatient clinics is of high quality. In addition, we identified specific areas that could be further optimized. Furthermore, the potential clinical impact of new developments such as gender-specific target dosages and new heart failure drugs have been assessed.

Depending on the severity of heart failure, different monitoring strategies might be indicated. Non-invasive remote monitoring might be indicated in less symptomatic heart failure patients, while more symptomatic patients might benefit more from remote hemodynamic monitoring. Furthermore, we have identified potential new areas to implement remote hemodynamic monitoring, including the monitoring of valvular heart diseases, heart failure patients on the heart transplantation waiting list as well as patients going for left ventricular assist device surgery.

We demonstrated that the hybrid construction of remote hemodynamic monitoring and left ventricular assist support is safe and feasible for the first time prospectively. The hemodynamic feedback can be used to identify patients at very high risk for left ventricular assist device-related complications. Additionally, remote hemodynamic monitoring can be used to determine the ideal surgery window and allows for remote outpatient monitoring and optimization.

We have identified several challenges in left ventricular assist device management, which could be addressed to optimize and individualize the left ventricular assist device care. Our results highlight the importance of careful consideration of whether concomitant aortic valve surgery is indicated during left ventricular assist device surgery.

Due to corona, the PhD defences do not take place publicly in the usual way in the Senate Hall of the Professor Andries Querido Room. The candidates will defend their dissertation either in a small group or online.

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