PhD defence S. (Sunrui) Chen

The development of rotavirus vaccines has made huge impact on global burden of rotavirus infection (1). This positive development has however diminished attention to quest for successful combat against rotavirus infection. However, the mortality of rotavirus disease remains considerably high in developing countries, especially in sub-Saharan Africa and southeast Asia (2). Additionally, some organ transplanted patients and IBD patients are still under the risk of contracting rotavirus infection (3). Moreover, recent research and case reports showed that rotavirus might be one of the viral causes of biliary atresia (4). So, investigation on rotavirus and focusing on antiviral treatment is still needed. This consideration led me to start research described this thesis, and here I want to summarize the result and outline my comprehension as what these results tell us.

Due to corona, the PhD defences do not take place publicly in the usual way in the Senate Hall of the Professor Andries Querido Room. The candidates will defend their dissertation either in a small group or online.