PhD defence A.V. (Alex) Neagu
- Prof.dr. E.A. Dzierzak
- Prof.dr. D.F.E. Huylebroeck
On Tuesday 14 January 2020, A.V. Neagu will defend his PhD dissertation, entitled: ‘Signal Balance as a Pluripotency Determinant - In vitro modeling of in vivo pluripotency states with WNT, FGF and BMP’.
The focus of this thesis is on extending our knowledge on stem cell biology by investigating different aspects of pluripotency in mouse and human pluripotent stem cells. Specifically, we aimed to thoroughly describe the effect key signaling pathways have on pluripotency, with a particular view towards providing a more complete view of the controversy of the role of WNT signaling in pluripotency. This thesis aimed to investigate the major differences between naive and primed pluripotent cells derived from both mouse and human, the balance between various signaling pathways that lead to pluripotency maintenance or exit, and how downstream effectors lead to different pluripotency states.
This thesis enriches the body of knowledge around pluripotency by describing a novel pluripotent state. It deepens our understanding of cell biology, the processes establishing pluripotency and provides new insights into improving the process of artificial generation of pluripotent cells.
The public defence will take place at the Prof. Andries Queridoroom, 3rd floor Education Center, Erasmus MC. The ceremony will begin exactly at 13.30 hrs. In light of the solemn nature of the ceremony, we recommend that you do not take children under the age of 6 to the first part of the ceremony.