On Wednesday 17 June 2020, B.D. van Groen will defend her PhD dissertation, entitled: ‘From Baby Steps To Mature Strides. Maturation of drug metabolism and transport studied using innovative approaches’.
Drug disposition in children is impacted by developmental changes in drug absorption, distribution, metabolism and excretion. This mandates the need for dosing regimens specifically tailored to children. Yet, there are gaps in the knowledge on these developmental changes, for example regarding hepatic and renal drug transport and cytochrome P450 (CYP)3A metabolism, putting children at risk for subtherapeutic or toxic drug exposure. Pediatric drug research is faced with ethical and analytical challenges. This thesis addresses these knowledge gaps and challenges by using innovative study designs.
The PhD defences will not take place publicly in the Senate Hall or Professor Andries Queridoroom due to the coronavirus. The candidates will defend their thesis online.